E.J. Manuel scrambled for a big first down as Buffalo got into the red zone, but as he moved down the sideline, he got drilled and came up grabbing his knee. Jeff Tuel, who almost started the opener when Manuel was out in the preseason, is now in the game. Get out of bounds after the first down, Manuel! We are now down to both quarterbacks who started the game being out, as Brian Hoyer left earlier after twisting his knee.