You say San Diego, and we immediately think of Tony Gwynn, perfect weather, partying prior to the 2003 Super Bowl, and this oft-quoted exchange in Anchorman:

Ron Burgundy: Discovered by the Germans in 1904, they named it San Diego, which of course in German means a whale’s vagina.
Veronica Corningstone: No, there’s no way that’s correct.
Ron Burgundy: I’m sorry, I was trying to impress you. I don’t know what it means. I’ll be honest, I don’t think anyone knows what it means anymore. Scholars maintain that the translation was lost hundreds of years ago.
Veronica Corningstone: Doesn’t it mean Saint Diego?
Ron Burgundy: No. No.
Veronica Corningstone: No, that’s – that’s what it means. Really.
Ron Burgundy: Agree to disagree.

And heretofore, when someone says San Diego, we’ll think of this TJ Simers column. In a word: brilliant. “The Chargers have been picked by some experts to win the Super Bowl, but the Spanos Goofs and their band of heartbreakers regularly fall shy of expectations, which might explain why the team was the only one unable to sell out the opener — a TV station buying tickets so the game could be shown here locally.”

Wow.

San Diego is a town filled with losers (LA Times)